As a Post-doctoral Research Fellow working in the Hepatitis C Virus (HCV) Research Group my primary interest is how HCV manipulates intracellular signaling pathways to initiate and potentiate infection of hepatocytes within the liver. Using an in vitro cell model I recently identified the importance of the cellular kinase protein kinase A (PKA) and consequently the role of the cAMP signaling pathway in HCV infection, furthermore I was able to demonstrate the significance of this pathway in primary human hepatocytes. My current research involves studying the function of the HCV receptor CD81 in virus internalization and the trafficking of CD81, Claudin-1, Occludin and Scavenger Receptor BI, proteins identified as important HCV entry factors, within cells.
Synopses of Michelle's work
Hepatitis C virus induces CD81 and claudin-1 endocytosis. Farquhar et al, J. Virology 2012
Hepatitis C virus entry and the tetraspanin CD81. Farquhar et al. Biochemical Soc, trans. 2011 (review).
Protein Kinase A dependent step(s) in Hepatitis C virus entry and infectivity Farquhar et al, J. Virology 2008
Primary hepatocytes as targets for Hepatitis C virus replication. Farquhar & McKeating, J. Viral Hepatitis, 2008
"If at first you don't succeed try, try again"
Michelle J. Farquhar
HCV Research Group
Institute of Biomedical Research,
School of Immunity and Infection,
College of Medical and Dental Sciences,
University of Birmingham, Birmingham B15 2TT UK
Tel: (44) 121 414 6845
Fax: (44) 121 414 3599
E-mail: Michelle Farquhar
PubMed listed Publications
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